Expansion of the genetic code via expansion of the genetic alphabet
نویسندگان
چکیده
منابع مشابه
phylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran
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Expansion of the Genetic Alphabet: Unnatural Nucleobases and Their Applications
1Department of Chemistry, Indian Institute of Technology Guwahati, Gumahati 781039, India 2Department of Chemistry and Center for Cell & Genome Science, The University of Utah, Salt Lake City, UT 84112, USA 3Department of Chemical Biology and Applied Chemistry, School of Engineering, Nihon University, Koriyama, Fukushima 963-8642, Japan 4Department of Chemistry, Roy and Diana Vagelos Laboratori...
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Nature has invented photoreceptor proteins that are involved in sensing and response to light in living organisms. Genetic code expansion (GCE) technology has provided new tools to transform light insensitive proteins into novel photoreceptor proteins. It is achieved by the site-specific incorporation of unnatural amino acids (Uaas) that carry light sensitive moieties serving as "pigments" that...
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More than one third of all proteins are metalloproteins. They catalyze important reactions such as photosynthesis, nitrogen fixation and CO2 reduction. Metalloproteins such as the olfactory receptors also serve as highly elaborate sensors. Here we review recent developments in functional metalloprotein design using the genetic code expansion approach. We show that, through the site-specific inc...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2018
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2018.08.009